Originally posted by Madison boxing
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At the end of the day you can perform trial after trial but when your trials start getting into the kinds of numbers required to uncover these rare side effects you essentially already had a de-facto rollout. And in the case of a rapidly spreading infectious disease outbreak it becomes necessary to make the call. Effectively all you can ever do is test it well enough - within the limits of practicability - to demonstrate that the vaccine is overwhelmingly safer than the disease it's meant to cure and then you roll the dice....
That's the whole purpose of vaccine surveillance systems man. To try to catch these kinds of effects that don't become apparent untill you've vaccinated millions. In effect the vaccine surveillance systems are the ongoing trial... that's the only practical way you can uncover these rare effects.
End of the day none of the rare side effects found bring the risks of vaccination close to the risks from getting COVID except in the under 18s (and even then the balance favours vaccination except where case rates are very low). As I said previously though the whole risk/ reward thing is gonna have to be reassessed somewht in the light of Omicron - and of course in the light of the almost total coverage of either vaccination or prior infection (reckoned at about 97% in the UK) that we got after 2 years of this crap.
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