In a card streaming on ESPN+ this Wednesday, October 30, light flyweight Rene Santiago will clash with Azael Villar in the 10-round main event. The bout will take place at Coliseo Marcelo Trujillo Panisse in Humacao, Puerto Rico. The card is available on ESPN+ exclusively in the United States. Coverage will begin at 8pm ET/5pm PT.

Santiago, 12-4 (9 KOs), made his pro debut in November 2014. He is coming off a successful 2023, in which he earned a ninth-round TKO against Carlos Ortega and stopped then-unbeaten Kevin Vivas in the 12th round. The 32-year-old just had his first world title opportunity, a unanimous decision loss against Jonathan Gonzalez in March. Villar, 21-3-4 (15 KOs), returns after decisioning Vivas in eight rounds in July.

Earlier bouts on the card include a flyweight matchup between Juan Carlos Camacho, 17-1 (8 KOs) and Jayson Mama, 20-1 with 10 stoppages. The bout is scheduled for 10 rounds.

The 11-0 (8 KOs) Christian Barreto faces off with Miguel Marrero, 10-1-2 (4 KOs) in a six-round lightweight clash.

Lightweight Nicolas Polanco, 22-7-1, (13 KOs) takes on the 23-6-1 (16 KOs) Leonardo Padilla (23-6-1, 16 KOs) in an eight-rounder.